User:Herb5902/Gynostemma pentaphyllum

Jiaogulan (Southern Ginseng)

over 80 different saponins including GYPENOSIDES
actiponin
Ginsenosides

Benefits:

Mitigates the Diabetic Nephropathy through Down-regulating mTOR
Prevents and treats of acute renal failure by improving renal tubule congestion and renal tubule epithelial edema
G. pentaphyllum contains two novel dammarane-type saponins designated as damulin A (1), 2α,3β,12β-trihydroxydammar-20(22)-E,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], and damulin B (2), 2α,3β,12β-trihydroxydammar-20,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], that strongly activate AMPK
- AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose, lipid, and energy metabolism
- Damulins A and B also increases:
  - β-oxidation and
  - glucose uptake by
  - increasing GluT4 translocation
Diabetes
- improves insulin sensitivity
- may also help in the production of insulin
Activates AMPK and
Inhibits the insulin regulator PTP1B
Induces antioxidant enzymes
Promotes the transcription factor NRF2
Increases mitochondrial metabolism by activating the PGC-1α pathway
Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway
Allergies
- boosts Th1 cell production by activating PPAR alpha
- reduces histamine production
anti-inflammatory
REDUCTION OF HEADACHES
Cancer (inducer of p53)
Aging
Exercise endurance

Adverse effects:

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