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Thymosin Beta-4 is a peptide consisting of 43 amino acids. In animal models, Thymosin Beta-4 has demonstrated the ability to enhance blood vessel growth, regulate wound healing, decrease inflammation, and reduce oxidative damage in both the heart and central nervous system. It plays a significant role in protecting, repairing, regenerating, and remodeling injured or damaged tissues. Additionally, Thymosin Beta-4 has garnered considerable attention in anti-aging research.

Product Details of [ TB-500 ]

  • Name:TB-500
  • Sequence: A-Ser-Asp-ys-r-Asp-M-l-lle-Glu-Lys-Phe-Asp-Lys-Ser-ys-Leu-Lys-y-Th-Glu-Th-Gin-Glu-Lys-Asn-Pro-Leu-Pro-5er-ys-Cn-1-1le-Glu-Gin-Glu-Lys-GIln-AIa-Gly-Glu-Ser
  • Molecular formula:C212H350N58078S
  • Molar Mass: 4063.4408
  • CAS number: 77591-33-4
  • PubChem: CID 16132341
  • Synonyms: Thymosin Beta 4

TB-500 Research

Thymosin Beta 4, also known as TB-500, is a synthetic form of a naturally occurring peptide composed of 43 amino acids. This peptide is found in almost all studied human and animal cells. [2] A study published in the Annals of the New York Academy of Sciences in 2010 provided support for the potential of TB500 in repairing cardiac muscle after injury, such as myocardial infarction (heart attack). This is particularly significant considering the limitations of stem cell therapy in this context. The study revealed that TB500 has the ability to prevent myocardial cell death, promote blood vessel growth, and activate cardiac processes that facilitate the healing of the heart following injury. It suggested that TB500 could be the first agent capable of actively restoring damaged cardiac muscle after a heart attack. Previous studies conducted on mice in 2004 also demonstrated the migration, survival, and repair of cardiomyocytes in cases of myocardial damage. Filamentous actin (F-actin), also known as actin, is responsible for the formation of polymers that contribute to the thickening of sputum, which has a negative impact on patients with cystic fibrosis (CF).In a study conducted on CF patients, TB500 was investigated, and it demonstrated a decrease in the cohesivity of sputum in a dose- and time-dependent manner when used in combination with dornase alfa. The combination therapy resulted in a notable 71% improvement in the mucociliary transport of mucus and a 44% improvement in the cough transport of mucus.

TB500 has been recognized for its ability to stimulate myoblasts and myocytes, which are cells involved in muscle generation. Studies have indicated that following muscle injury, the levels of mitochondrial RNA associated with TB500 increase. This increase in TB500 helps in the regeneration of muscle fibers and reduces inflammation in the injured area. The findings suggest that muscle injury triggers the local production of TB500, which facilitates the migration of incoming myoblasts and accelerates the process of skeletal muscle regeneration.


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