Hinokitiol (β-thujaplicin) is a natural monoterpenoid found in the wood of trees in the family Cupressaceae.
Hinokitiol was first extracted from Taiwanese hinoki in 1936.
Anti bacterial activity
Hinokitiol has a broad range of biological activities, many of which have been explored and characterised in literature. Recent research has shown that Hinokitiol has potential antimicrobial activity against many bacteria and fungi, including some antibiotic resistance bacteria e.g MRSA(Methicillin resistant Staphlococcus Aureus). Specifically, Hinokitiol has been shown to be effective against Streptococcus pneumoniae, Streptococcus mutans and Staphylococcus Aureus, common human pathogens. Additionally, Hinokitiol has been shown to possess inhibitory effects on Chlamydia trachomatis and may be clinically useful as a topical drug.
More recent studies have shown that Hinokitiol also demonstrates anti-viral action when used in combination with a zinc compound against a several human viruses including rhinovirus, coxsackievirus and mengovirus. It has been proposed that Hinokitiol inhibits viral replication by impairing viral polyprotein processing.
Hinokitiol is known to posses anti-inflammatory and anti-tumour activities which has been demonstrated in a number of in vitro cell studies and in vivo animal studies. Hinokitiol inhibits key inflammatory markers and pathways, such as TNF-a and NF-kB, and its potential for treatment of chronic inflammatory or autoimmune conditions is being explored. Hinokitiol was found to exert cytotoxicity on several prominent cancer cell lines by inducing autophagic processes.
Zinc deficiency has been demonstrated in some cancer cells and returning optimum intra-cellular zinc levels can lead to suppression tumor growth. Hinokitiol is a documented Zinc Ionophore, however more research is required at this time to establish effective concentrations of delivery methods for Hinokitiol and Zinc.
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